Background: Cell therapy has emerged as a promising curative intervention for several diseases including diabetes and Wolfram Syndrome (WS).The current study aimed to assess the effectiveness of clinical application of fetal-liver derived stem cells for treatment of patients with WS.Methods: fortiflex stable super fork - head only Six patients with WS aged 23-34 (mean: 29.50, SD: 4.
76) were recruited for the current phase 3 single-arm clinical trial.The participants underwent fetal liver-derived hematopoietic stem cell transplantation.In order to evaluate the effectiveness of transplantation, glycemic control indexes were measured at regular follow-up sessions.Results: One patient (out of six) experienced smartgiro a 6 months insulin-free period with acceptable HbA1c levels.
In another patient with history of recurrent hypoglycemic attacks, the frequency of bout of attacks remarkably decreased.There was no significant change in other patients.Conclusion: Stem-cell therapy may represent a new method for treatment of patients with Wolfram Syndrome.Keywords: Stem Cell, Allotransplantation, Wolfram Syndrome, Diabetes.